Nutrition for Precision Health, powered by the All of Us Research Program: Research Coordinating Center (U24 Clinical Trial Not Allowed) | RFA RM 21 006

Opportunity Information: Apply for RFA RM 21 006

This funding opportunity (RFA-RM-21-006) is an NIH Cooperative Agreement (U24; clinical trial not allowed) to support a single Research Coordinating Center (RCC) for the Nutrition for Precision Health (NPH) consortium, an NIH Common Fund effort powered by the All of Us Research Program. The central idea behind NPH is to generate stronger evidence on how different people respond to diet, then turn that evidence into usable approaches and algorithms that can improve the precision of nutrition guidance at the individual level. Rather than funding another standalone research site, this award is designed to fund the coordinating hub that keeps the whole consortium aligned, operational, and productive.

The RCCs core role is consortium-wide coordination. That includes day-to-day administrative management, organizing and supporting governance activities, coordinating communication across multiple projects and stakeholders, and helping ensure that the consortium moves forward on shared milestones and deliverables. Because NPH involves multiple dietary intervention and dietary assessment studies being carried out across the consortium, the RCC is also expected to help facilitate how those studies are developed and implemented so that methods are compatible enough to support cross-study analyses and shared outputs. In practice, that typically means harmonizing research protocols, aligning common measures, supporting operational planning, coordinating timelines, and helping resolve issues that arise when several teams must execute related work in parallel.

A major emphasis of this RCC is data stewardship and data workflow management. The notice makes clear that NPH data are expected to be shared through the All of Us Researcher Workbench, and that participants enrolled in the NPH dietary studies are anticipated to be All of Us participants as well. This creates an unusually tight integration between a nutrition-focused consortium and a large national research platform, and the RCC is expected to function as a key partner to All of Us to make that integration work smoothly. That partnership responsibility implies managing data sharing workflows end to end, coordinating standards and formatting so data can be ingested and used appropriately, supporting documentation and metadata needed for reuse, and working through privacy, access, and governance expectations that accompany a platform like the Researcher Workbench.

The intended end products reflect those priorities. NIH is looking for (1) a rich, well-managed data resource that the broader research community can use and (2) algorithms or analytic approaches that can help improve the precision of nutrition advice for individuals. The RCC is not positioned as the group that runs the dietary studies itself, but rather as the group that ensures the studies can collectively produce interoperable, high-quality data and that the resulting data resource and related deliverables are usable, discoverable, and effectively shared via the All of Us ecosystem.

Eligibility is broad and includes many typical NIH applicant categories: state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, HBCUs, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign institutions (non-U.S. entities) are not eligible to apply as the applicant organization, but non-domestic components of U.S. organizations may participate, and foreign components (as NIH defines them) are allowed, which matters for teams that need specific expertise, collaborations, or operational capacity outside the U.S. while still maintaining a U.S.-based applicant organization.

From an administrative standpoint, the opportunity is listed under the NIH as the sponsoring agency, categorized as discretionary funding, and associated with CFDA 93.310. The original application closing date shown is April 6, 2021, and the funding instrument is a cooperative agreement, which generally means substantial NIH programmatic involvement is expected during the project period. In other words, this is not a hands-off grant where the awardee operates independently; the RCC is expected to work closely with NIH, the NPH consortium investigators, and the All of Us program to coordinate decisions, implement shared processes, and deliver consortium-level products.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Nutrition for Precision Health, powered by the All of Us Research Program: Research Coordinating Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
• This funding opportunity was created on 2021-01-21.
• Applicants must submit their applications by 2021-04-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA RM 21 006

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